Keith Klein has worked for the Atomic Energy Commission and the U.S. Department of Energy since graduating from undergraduate school. In this interview, he recounts the timeline of his tenure with the AEC and DOE. He held positions on their Liquid Metal Fast Breeder Reactor program, nuclear waste disposal, and with Tritium production. Klein was active in the efforts to clean up the Rocky Flats plant site after the FBI raid in 1989 and coordinated the opening of the Waste Isolation Pilot Plant (WIPP) in Carlsbad, New Mexico. He oversaw the DOE’s cleanup effort at Hanford, and was fundamental in establishing DOE’s Office of River Protection. Klein speaks to the current debate and myths surrounding nuclear waste cleanup, the challenges that remain and the progress that has been made, and his vision for the future.